They also stated that it activated JAK/STAT and PI3K/AKT pathways in HCC.147 Similar to HOTAIR and HULC, MALAT1 participates in HBx‐triggered hepatocarcinogenesis, since its expression is increased by HBx, thereby enhancing metastasis and proliferation through LTBP3 activation as well as the formation of the HBx‐MALAT1‐LTBP3 axis.148 To this end, we summarize that MALAT1 modulates many processes which are essential to HCC progression, and hence has the potential to be a target for HCC treatment. Here, AKT1 is linked to hepatocellular carcinoma.