In term of its function in HCC, HOTAIR facilitates many cellular processes such as cell chemoresistance, autophagy, glycolysis, migration, and proliferation.138 A study reported that HOTAIR orchestrated the suppression of miRNA‐218‐induced Bmi‐1 expression and enchained the signaling by P14 and P16, which led to increased hepatocarcinogenesis.135 FOXC1 increased the level of HOTAIR by inhibiting miR‐1 in HCC cells, an effect that accelerates cell proliferation. The gene discussed is HOTAIR; the disease is hepatocellular carcinoma.