CUL2 and neoplasm: Before they become metastatic and invasive, tumor cells undergo epithelial‐mesenchymal transition (EMT), which is characterized by increased vimentin and loss of E‐cadherin.71, 72 It was reported that the EMT‐inducing transcription factor, Twist 1 increased the expression of Cul2 circRNA (circ‐10720).68 A positive correlation was found between circ‐10720 and tumor malignancy and poor HCC progress.