139 Furthermore, HOTAIR may promote HBV‐ induced HCC by boosting the breakdown of ZNF198 and SUZ12.140 It was shown that HOTAIR triggered autophagy in HCC cells via its positive effects on ATG7 and ATG3.141 In conclusion, HOTAIR plays important roles in the initiation of HCC via multi‐pathway mechanisms. The gene discussed is ATG3; the disease is hepatocellular carcinoma.