This finding showed that MEG3 may have tumor suppressive function in HCC.163 Also, MEG3 was identified to be a molecular sponge for miR‐664 inhibiting cell proliferation via miR‐664‐dependent ADH4 regulation.166 In summary, these findings implicate MEG3 as an anti‐tumor agent, which can be exploited in the diagnosis as well as in the treatment of HCC. This evidence concerns the gene MEG3 and neoplasm.