HOTAIR (HOX transcript antisense intergenic RNA) refers to a lncRNA derived from HOXC antisense strand.133 The expression of HOTAIR is high in HCC tissues and cells.134, 135, 136, 137 And it has shown to affect the clinical outcomes of patients with HCC in terms of promoting recurrence risk following hepatic transplantation, causing shorter recurrence‐free survival, and predicting poor prognosis. The gene discussed is HOTAIR; the disease is hepatocellular carcinoma.