However, the expression of ASNS in ALL did not compromise ASNase effectivity (Vander Heiden & DeBerardinis, 2017), indicating that the ubiquitous activation of the GCN2‐ATF4‐ASNS axis in response to nutrient deprivation might be essential, but not sufficient to induce ASNase resistance. The gene discussed is ATF4; the disease is acute lymphoblastic leukemia.