However, the expression of ASNS in ALL did not compromise ASNase effectivity (Vander Heiden & DeBerardinis, 2017), indicating that the ubiquitous activation of the GCN2‐ATF4‐ASNS axis in response to nutrient deprivation might be essential, but not sufficient to induce ASNase resistance. Here, EIF2AK4 is linked to acute lymphoblastic leukemia.