The molecular pathways related to lipid metabolism, for example, the biosynthesis of cholesterol, steroid and mevalonate, and the gene expression related to sterol regulatory element‐binding protein (SREBP), have been strongly impaired in all three cancer cell lines when SLC1A3 was either chemically blocked or intrinsically absent following ASNase treatment (Fig 4A–C). The gene discussed is SLC1A3; the disease is cancer.