KMT2A and cancer: The most significant pathway affected was transcriptional misregulation in cancer, which was enriched with up-regulated DEGs, including MEF2C, PROM1, CEBPA, LMO2, FLT3, RUNX1, HMGA2, RUNX2, MEIS1, MYC, and WT1. Some of these genes have been defined as MLL targets genes.