The results indicated that the hub genes MYC, ALB, CD44, PTPRC and TNF, together with some biological events including negative regulation of apoptotic processes, monocyte differentiation, homophilic cell adhesion, and transcriptional misregulation, may contributed to leukemogenesis, migration, and invasion in MLL-R infant ALL. Here, KMT2A is linked to acute lymphoblastic leukemia.