Some preclinical studies have suggested that uric acid might directly influence fat accumulation and hepatic steatosis by inhibiting insulin signaling to cause insulin resistance (Zhu et al., 2014), inducing mitochondrial oxidative stress (Lanaspa et al., 2012) or generating endoplasmic reticulum stress (Choi et al., 2014). The gene discussed is INS; the disease is Hepatic steatosis.