CD34 and myeloid leukemia: Here, following the analysis of the role of miRNAs during the differentiation of HL-60 cells through the neutrophilic lineage, we have found a novel miRNA signature during neutrophil differentiation, being upregulation of miR-125a-5p critical for the differentiation of myeloid leukemia cell lines (HL-60 and NB4) as well as of primary CD34+-hematopoietic progenitor/stem cells (CD34+-HPCs) into human neutrophil-like cells.