PPARG and malignant colon neoplasm: High enrichment of fat cell differentiation term in the SM-treated samples can be explained by the effect of SM on PPARγ, playing a key role in adipocyte differentiation [52] – previously, it was found that CDODA-Me had agonist activity on PPARγ (1-5 μM; SW480 colon cancer cells (20–22 h)) [53].