Previously, EFNA1 and TFRC have been proposed as prognostic factors in CESC [129, 131] and were found to be sensible to natural compounds – it was shown, that (-)-epigallocatechingallate and curcumin treatment, similar to SM, significantly decrease expression of EFNA1 and TFRC in tumor cells, respectively [132, 133]. This evidence concerns the gene TFRC and cervical squamous cell carcinoma.