KLF4 and colonic neoplasm: Observed SM-induced up-regulation of KLF4 is in accordance with published data: it was shown that CDODA-Me and cyano enone-bearing derivative of betulinic acid induced KLF4 expression in colon cancer cells (1-5 μM (SW480, HT-29, HCT-15 cells (12 h)) and 5-10 μM (SW80, HT-29 cells (24 h)), respectively) [53, 126].