Among the identified highly enriched functional groups, three detected terms were also associated with antiviral response, including “viral process”, “response to virus” and “hepatitis C and hepatocellular carcinoma”, which contained DEGs involved in the regulation of innate antiviral immunity (IFIT1, IFIT2, IFIT3, IFI16, ISG15, ISG20, LCN2, LGALS8, etc.). The gene discussed is ISG15; the disease is hepatitis C virus infection.