CCN2 and renal fibrosis: In the angiotensin II-treated murine model, KLF15 was likely to inhibit the expression of angiotensin II-induced profibrotic connective tissue growth factor (CTGF) by suppressing the recruitment of the co-activator p300/CREB-binding protein-associated factor (P/CAF) to the CTGF promoter, thus exerting an early antifibrotic effect in renal fibrosis 18.