For example, overexpression of FGFR2 promotes the proliferation and survival of gastric cancer cells through activating the downstream MAPK/ERK and PI3K/AKT signaling pathways 10, and FGFR2 enhances the phosphorylation activity of RSK2 and regulates the migration of human mammary epithelial cells 11. This evidence concerns the gene FGFR2 and gastric cancer.