Further study demonstrated that circ-PDE8A promotes the invasive growth of PDAC cells via the miR-338/MACC1/MET or AKT pathways.74 Recently, this research group showed that another circRNA (circ-IARS) could enter human microvascular vein endothelial cells (HUVECs) through exosomes and promote PC invasion and metastasis followed by increased endothelial monolayer permeability. This evidence concerns the gene PDE8A and pachyonychia congenita.