As a powerful superantigen, staphylococcal enterotoxin (SEB) has shown its ability to stimulate not only T cell proliferation and activation but the Fas-mediated apoptotic pathway.134 Mahmoodzadeh Hosseini et al. demonstrated that hybrids of MIA PaCa-2 exosomes and SEB (EXO/SEB) promote anti-proliferative effects and cell death in PC cells.135 The results highlight the potential of reprogramming of exosomes as a therapy in PC treatment. This evidence concerns the gene SETBP1 and pachyonychia congenita.