In contrast, the presence of functional Cry1/2 and Bmal1may play a role in preventing CJL mediate cancer development by interacting with cancer-associated genes that were reported playing role in cancer including Tspan3264,65, Rap1gap78, Prkaa279,80, Fzr168, Gsk3b70, Dlg161, Klf581,82, Akt172,79,83, Araf84, Ccnd185, Pik3r175 and Prdm1676,77. The gene discussed is CRY1; the disease is cancer.