Similarly, lacking functional Bmal1may increase the CJL mediated glioma risk via downregulating the previously reported tumor suppressor genes Bin153, Tspan3264,65, Dact166,67, Fzr168, Gpsx355,69, and Gsk3b70, whereas lacking functional Cry1/2, may play a role in preventing CJL mediated cancer via downregulating the oncogenes Akt171,72, Kras73,74, Pik3r1 (75)and Prdm76,77, which have been reported as oncogenes that promote cancer metastasis and proliferation. This evidence concerns the gene PIK3R1 and cancer.