PIK3R1 and central nervous system cancer: Similarly, lacking functional Bmal1may increase the CJL mediated glioma risk via downregulating the previously reported tumor suppressor genes Bin153, Tspan3264,65, Dact166,67, Fzr168, Gpsx355,69, and Gsk3b70, whereas lacking functional Cry1/2, may play a role in preventing CJL mediated cancer via downregulating the oncogenes Akt171,72, Kras73,74, Pik3r1 (75)and Prdm76,77, which have been reported as oncogenes that promote cancer metastasis and proliferation.