The expression pattern of CHL1 was analyzed with qPCR using samples obtained from 95 primary NPC patients (patient that has not received any form of treatment prior to the collection of the sample) and compared against the control (pool RNA from 10 non-tumor nasopharyngeal tissues), down-regulation of CHL1 was detected in 71/95 (74.7%) of NPC cases. Here, CHL1 is linked to neoplasm.