One clinical study indicated that serum levels of a variety of inflammatory factors are significantly increased during adult pulmonary arterial hypertension (idiopathic pulmonary arterial hypertension, IPAH) mediated by chronic hypoxia, including tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). The gene discussed is IL6; the disease is idiopathic pulmonary arterial hypertension.