The activation of NF-κB could be completely abolished by the mutation of the amino acid residues Trp24 and Pro41 in the COMM domain of COMMD6.21 Aberrant activation of the NF-κB signalling pathway has been observed in many human cancers, which induce tumour infinite growth and progression.22 Thus, we assumed that COMMD6 may be involved in the tumorigenesis and malignant progression. The gene discussed is NFKB1; the disease is neoplasm.