NFKB1 and cancer: The activation of NF-κB could be completely abolished by the mutation of the amino acid residues Trp24 and Pro41 in the COMM domain of COMMD6.21 Aberrant activation of the NF-κB signalling pathway has been observed in many human cancers, which induce tumour infinite growth and progression.22 Thus, we assumed that COMMD6 may be involved in the tumorigenesis and malignant progression.