These genes were prioritised as a Notch-Hedgehog signature potentially representative of multiple cancers: JAG1, LFNG, DTX2, DLL3, GPR161, PSENEN, GLI1, HES1, PTCRA, DTX3L, ADAM17, KIF7 and NOTCH1 (Fig. 1c). This evidence concerns the gene ADAM17 and cancer.