IGF1 and acromegaly: As a result of the excess secretion of GH and IGF-1, individuals with acromegaly may experience changes to their facial appearance and enlargement of the hands and feet, as well as active acromegaly symptoms such as headache, sweating, fatigue, soft tissue swelling and joint pain; other comorbidities include sleep apnea, hypertension, diabetes mellitus, bone disease, and cardiovascular disease [4].