In a GWAS of alcohol use in ~480,000 subjects of European descent to decipher the genetic architecture of alcohol intake (https://www.biorxiv.org/content/biorxiv/early/2018/10/30/453332.full.pdf), authors identified 46 novel loci (which included the SLC39A8 Ala391Thr variant), and investigated their potential functional significance using MRI, gene expression, and behavioral studies in Drosophila; the newly identified genetic pathways associated with alcohol consumption suggested common genetic interactions with several neuropsychiatric disorders including schizophrenia. The gene discussed is SLC39A8; the disease is schizophrenia.