Meta-analysis of GWAS data from >46,300 individuals of European, African, East Asian, and Hispanic ancestry was carried out to identify, and functionally test, novel genetic associations regulating the coagulation factor-8 (FVIII) and its carrier protein von Willebrand factor (VWF) plasma levels, with risk of arterial and venous thrombosis. Here, VWF is linked to Venous thrombosis.