SLC39A8 and inflammatory bowel disease: In order to identify novel variants associated with IBD, whole-exome sequencing of >10,500 IBD cases and ~ 5720 non-IBD controls revealed an association between Crohn disease (CD) and the SLC39A8 p.Ala391Thr variant; in two replication cohorts [62], combined meta-analysis was highly significant (P = 5.6 × 10−13); this finding is consistent with the large GWAS of 42 traits or diseases, mentioned earlier [50].