Given the relevance of NFκB in immune pathways and asthma, genomic-sequencing experiments were performed to identify intronic NFKB1 SNVs that might regulate expression of neighboring genes; among genes within 1 Mb of the NFKB1 gene as a reliable cutoff, the low bronchodilator-response-associated T allele of the Chr 4 g.102532378C>T NFKB1 intronic variant was found to be significantly associated with decreased SLC39A8 mRNA expression in white blood cells (P = 0.0066, FDR-adjusted P = 0.0856, log2(β) = − 0.327) [44]. This evidence concerns the gene NFKB1 and asthma.