Keeping in mind that mice receiving a Zn-deficient diet develop disproportionate inflammation in response to polymicrobial sepsis—along with NFκB activation and loss of normal IKK regulation [45]—these data indicate that ZIP8 participates in a negative feedback loop directly involved in regulation of innate immune function via coordinated Zn metabolism [45]. This evidence concerns the gene NFKB1 and Sepsis.