SLC39A8 and alcohol dependence: In a very recent study on the genetic architecture of alcoholism — a meta-analysis of more than 480,800 people of European descent identified 46 novel common genetic loci and investigated their potential functional importance, using magnetic resonance imaging and gene expression studies [103]; one of the genes highest on the list of statistical significance was the SLC39A8 p.Ala391Thr variant (P = 1.3 × 10–15).