Researchers designed two genetically engineered mouse models bearing high-grade serous ovarian cancer: PBM (driven by p53 depletion, BRCA1 depletion, and c-Myc overexpression) and PPM (driven by p53 depletion, PTEN depletion, and c-Myc overexpression) [118]. This evidence concerns the gene MYC and ovarian serous adenocarcinoma.