ERCC1 and neoplasm: We assumed that the small sample tissue, as a commonest, and derived from bronchial biopsies, would be sufficient for IHC analysis of ERCC1 expression and representative for the total tumor despite of tumor heterogeneity, according to Taillade et al. who reported a high correlation for ERCC1 expression comparing bronchial biopsies and resected surgical specimens in the same patient [24].