Using TCR-like antibodies against peptide/MHC complexes of three major melanocyte differentiation antigens (gp100, Mart-1, and tyrosinase), Yael and colleagues found that melanoma cell lines had an average of approximately 4000 surface copies per cell of the complexes of HLA-A2 and tyrosinase (369–377) but only a few hundred copies per cell of gp100 and Mart-1 complexes [38]. This evidence concerns the gene PMEL and melanoma.