These mutations can lead to the expression of truncated proteins, fusion proteins, or neoantigens that are unique to cancer cells, such as beta-catenin S37F in melanoma [68], alpha-actinin-4 K122N in lung cancer [69], heat shock protein 70 kilodalton-2 (hsp70-2) F293I in renal cancer [70], Kirsten rat sarcoma viral oncogene (K-ras) G12D in colon cancer [71], myeloid differentiation primary response 88 (MYD88) L265P in hairy cell leukemia [72], and B cell receptor-Abelson murine leukemia viral oncogene homolog 1 (BCR-ABL) fusion protein in chronic myeloid leukemia [73]. This evidence concerns the gene MYD88 and melanoma.