IL10 and neoplasm: Tumor cells reside in hidden sites to prevent the access of T cells, generate a hypoxic environment, and secrete a large amount of immune-suppressive cytokines, such as interleukin 10 (IL-10), transforming growth factor beta (TGF-β), or other molecules that cause the T cells, NK cells, macrophages, or monocyte to experience anergy or death [124, 128].