These T cells could also lyse MAGE-A1+/HLA-A1+ target cells but not control MAGE-A1-/HLA-A1+ or MAGE-A1+/HLA-A1- tumor cells, indicating that the lysis of tumor cells via TCR-like antibodies was HLA-restricted and antigen-dependent. This evidence concerns the gene MAGEA1 and neoplasm.