IL1B and psoriasis: Notably, several studies have found that the IL-1β level was higher in the active phase of psoriasis and reduced in psoriatic patients after treatment consequently [98, 99]; meanwhile, a positive correlation between the serum levels of IL-1β with PASI has also been reported in psoriatic patients before and after treatment [100–102], signifying that IL-1β is an important mediator in the initiation and maintenance of psoriatic plaques.