Moreover, high baseline Hb values (OR = 1.7, 95% CI: 1.2–2.2; P-value< 0.001) and CRP hematic levels (OR = 1.2, 95% CI: 1.0–1.5; P-value = 0.060) were associated to ESA hyporesponsiveness in CKD (Table 3), while high baseline Hb values (OR = 1.7, 95% CI: 1.1–2.4; P-value = 0.007) and prior ischemic heart disease diagnosis (OR = 2.7, 95% CI: 0.9–7.9; P-value = 0.072) were predictors of ESA hyporesponsiveness in cancer patients (Table 4). The gene discussed is CRP; the disease is chronic kidney disease.