PRSS1 and familial pancreatic carcinoma: In our previous study, the PRSS1 mutations p.T135A, p.T137 M, and p.C139S were detected in pancreatic cancer patients, with the PRSS1_rs10273639 genotype impacting the clinical outcome of this malignancy (Liu et al., 2012; Liu et al., 2008; McWilliams et al., 2009).