F2RL1 and pancreatic neoplasm: Meanwhile, trypsinogen is specifically and highly expressed in the pancreas, and trypsin activates protease-activated receptor-2 (PAR-2); this results in cell cycle disturbance via the extracellular signal-regulated kinase (ERK) pathway, triggering pancreatic cancer occurrence (Jiang et al., 2010; Soreide et al., 2006).