AR and pachyonychia congenita: It should be noted that while c‐JUN acts on AR in luminal cells, it has increased expression in stromal cells where it regulates the AR cistrome (Leach and Buchanan, 2017; Leach et al., 2017) so the reduced stromal:luminal cell ratio that occurs in PC could contribute to the decrease in c‐JUN motifs seen in AR ChIP‐seq data from the tumor samples.