It should be noted that while c‐JUN acts on AR in luminal cells, it has increased expression in stromal cells where it regulates the AR cistrome (Leach and Buchanan, 2017; Leach et al., 2017) so the reduced stromal:luminal cell ratio that occurs in PC could contribute to the decrease in c‐JUN motifs seen in AR ChIP‐seq data from the tumor samples. This evidence concerns the gene JUN and pachyonychia congenita.