The role of c‐JUN in PC is more controversial but decreased c‐JUN expression has been correlated to worse PC clinicopathological outcomes (Edwards et al., 2004; Tamura et al., 2007), and c‐JUN has been shown to interact with AR and enhance DNA binding (Bubulya et al., 2001; Bubulya et al., 2000). This evidence concerns the gene JUN and pachyonychia congenita.