TSPO and Brain atrophy: Similar to [11C]PK11195, in vivo increases in TSPO binding are associated with impairments in global cognition and memory (Hamelin et al., 2018; Kreisl et al., 2013), but also extend to domains that include visuospatial and language ability, and executive functioning, in addition to dementia severity and brain atrophy (Hamelin et al., 2018; Kreisl et al., 2013; Kreisl et al., 2016; Suridjan et al., 2015).