MAPT and Alzheimer disease: [18F]THK5317 binding in the parahippocampal, fusiform, inferior, middle and superior temporal gyri, in addition to occipital areas, the middle frontal and posterior cingulate gyri, the parietal operculum, and precuneus were negatively related to cognition for patients along the AD continuum. Outcomes on FDG–PET showed a similar relationship with tau binding and mediated the effects of in vivo tau binding on cognition.