TSPO and Alzheimer disease: Medial frontal, parietal, and left temporal cortical areas demonstrated higher [11C]PK11195 retention for AD patients compared to controls. Additionally, uptake in the left anterior cingulate, left precuneus, left hippocampus, and left medial frontal cortex showed negative association with global cognitive performance. A similar inverse relationship was found for regional TSPO binding in the posterior cingulate cortex and amyloid uptake on [11]C‐PiB in this region.