MAPT and Alzheimer disease: Both MCI and AD patients showed increased tau binding in inferior temporal, lateral temporal, lateral occipital, inferior parietal, anterior frontal, lateral occipital cortex, in addition to the precuneus compared to healthy controls. Negative correlations between tau retention and FDG uptake were observed in the frontal cortex, while areas of the neocortex showed positive correlations between tau and amyloid binding on PET.