MAPT and early-onset autosomal dominant Alzheimer disease: For example, Pontecorvo et al. show that in a mixed group of Aβ positive subjects, increased tau ligand binding was correlated with global deteriorations in cognition as assessed by the Mini Mental Status Exam (MMSE) and Alzheimer's Disease Assessment Scale‐Cognitive Subscale (ADAS‐Cog) (Pontecorvo et al., 2017).