Additionally, although circumstantial, it is intriguing to note that the annexins, MG53, dysferlin and EHD1/2 all have links to sarcolemma microdomain (e.g. t-tubule and caveolae) stability and morphology and thus may also be involved in the adverse remodelling processes correlated to HF progression. The gene discussed is DYSF; the disease is hydrops fetalis.