HLA-DRB1 and autoimmune disease: As HLA-DR3 (both HLA-DRB1*03:01 and HLA-DRB3*02:02) has been shown to be involved in the pathogenesis of different autoimmune disease, gaining more insight into the peptidome presented by HLA-DR3 can extend the knowledge on how the HLA molecules participate in the induction (Berrih-Aknin 2014; Matzaraki et al. 2017).