Moreover, related enzymes such as Stearoyl-CoA desaturase (SCD; a rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids) are highly expressed in human prostate and breast cancers21,22, whereas a lower level of delta-6-desaturase (the main determinants of PUFA levels) has been observed in breast tumours compared with normal tissues23. This evidence concerns the gene SCD and breast neoplasm.