The reason for the PIP3 level decrease in the PCa tissues remains unclear; however, homozygous deletions of the PTEN locus occurred in just 15% of samples in a comprehensive molecular analyses of 333 primary prostate cancers using the TCGA database17, and a substantial amount of molecular heterogeneity has been observed in clinically extracted prostate cancer tissues. Here, PTEN is linked to Familial prostate cancer.