For GBM, most dominant SGAs are known drivers of this cancer type14,24,25 except MARCH9, AGAP2-AS1 (AGAP2 antisense RNA 1), CHIC2, GSX2, RYR2, MTAP, and TTN. For these genes, except MARCH9 and TTN, there is literature supporting that they are potential novel drivers of GBM. The gene discussed is AGAP2; the disease is glioblastoma.