RYR2 and glioblastoma: For GBM, most dominant SGAs are known drivers of this cancer type14,24,25 except MARCH9, AGAP2-AS1 (AGAP2 antisense RNA 1), CHIC2, GSX2, RYR2, MTAP, and TTN. For these genes, except MARCH9 and TTN, there is literature supporting that they are potential novel drivers of GBM.