It is worth noting that the plasma IL-35 level was positively correlated with the percentages of IL-35+ B cells (P < 0.0001, r = 0.9621; Fig. 3A) and IL-10+ B cells (P < 0.0001, r = 0.9686; Fig. 3B) in the new-onset SLE patients. Here, IL10 is linked to systemic lupus erythematosus.