Our results demonstrated that the percentages of IL-35+ Bregs (P = 0.0039, r = −0.4130; Fig. 6A) and IL-10+ Bregs (P = 0.0026, r = −0.4294; Fig. 6C) as well as the plasma IL-35 levels (P = 0.0053, r = −0.4004; Fig. 6E) were inversely correlated with the SLEDAI scores of the SLE patients. The gene discussed is IL10; the disease is systemic lupus erythematosus.