Additionally, the positive correlations between the frequency of CD27−CD38− naive B cells and the plasma IL-35 level (P = 0.0402, r = 0.3004; Fig. 5D), the frequency of IL-35+ B cells (P = 0.0438, r = 0.2954; Fig. 5E), and the frequency of IL-10+ B cells (P = 0.0327, r = 0.3120; Fig. 5F) were observed in the SLE patients. The gene discussed is IL10; the disease is systemic lupus erythematosus.