IL10 and systemic lupus erythematosus: Previous studies also have established that IL-35 can expand the numbers of IL-35+ Bregs and IL-10+ Bregs as well as induce IL-10 production12,25, which, combined with our findings, led us to hypothesize that IL-35 may function as a pivotal regulatory cytokine to promote the generation of Bregs by inducing naive B cells to develop into IL-35+ Bregs and IL-10+ Bregs as well as inhibiting the conversion of pathogenic plasma B cells in the pathogenesis of SLE.