Moreover, tumour-bearing DCs co-cultured with cryo-thermal eosinophils resulted in a significant down-regulation of immunosuppressive molecules, HO-1, STAT3, Foxo3, IDO2, VEGFR2 and PD-L1 as compared to tumour-bearing DCs co-cultured with tumour-bearing eosinophils. The gene discussed is IDO2; the disease is neoplasm.