The splenic eosinophils in cryo-thermal-treated mice expressed high level of chemokines and pro-inflammatory cytokines (CCL5, CXCL10, IFN-γ, IL-6, IL-12 and IL-15), which could create immunostimulatory microenvironment contributing to anti-tumour immunity25. The gene discussed is CXCL10; the disease is neoplasm.