IL6 and neoplasm: Furthermore, when macrophages were co-cultured with cryo-thermal eosinophils, the expression level of M1-associated co-stimulatory molecules and cytokines, CD86 and IL-12 were significantly up-regulated as compared to macrophages co-cultured with tumour-bearing eosinophils, and the expression of IL-6 was down-regulated (Fig. 5E).