CD274 and neoplasm: Moreover, blockade of IL-4 resulted in overexpression of pro-inflammatory cytokines (CXCL10, IL-1β, IL-15, IL-10 and IL-6) and lower expression of immunosuppressive molecules (Foxo3, IDO1 and PD-L1) as compared to cryo-thermal eosinophils + tumour-bearing DCs group (Fig. 5B,C).