Meanwhile, after the addition of IFN-γ neutralizing antibody, the relative expression level of pro-inflammatory cytokines (CXCL10, IL-1β, IL-15 and IL-6) was significantly reduced, and the gene expression of immunosuppressive molecules (HO-1, STAT3, Foxo3, IDO2, VEGFR2 and PD-L1) was increased as compared to cryo-thermal eosinophils + tumour-bearing DCs group, in addition, the level of IL-7 and IL-10 were up-regulated (Fig. 5B,C). Here, HMOX1 is linked to neoplasm.