We can conclude that overexpression/co-expression of the whole group of ALKBH proteins correlates with cancer development, including its different types, indicated by: (i) the high expression of almost all of the ALKBHs in HNSCC and in various cancer cell lines; (ii) decreased cancer cell viability following ALKBHs silencing; (iii) previously reported high expression of single ALKBHs in different types of cancer; (iv) the siRNA-treated mice with developed cancer show diminishing tendency of cancerous tissue. This evidence concerns the gene ALKBH1 and cancer.