RARA and acute myeloid leukemia: However, FTO may impact demethylation of selected transcripts, like in acute myeloid leukaemia where FTO plays a critical oncogenic role through demethylation of ASB2 and RARA mRNA (protein that are responsible for blood cell differentiation)21, also demethylation of RUNX1T1 (negative regulator of adicipogenesis)15, C/EBPβ (stimulator of hepatocytes and adipocytes growth)22, PPARγ (adipocytes differentiation)23, GAP-43 (growth of axons)24.