The expression of these inhibitory factors in TIPB is also in line with previous reports on human CD27intCD38+CD138− plasmablasts as a major IL-10+ B cell population45, the suppression of IL-17A+CD4+ T cells49 in human colorectal cancers being highly enriched for IL-10+CD19loCD27hi plasmablasts, and murine IgA+PD-L1+IL-10+ plasmocytes that prevent CD8+ T cell-mediated regression of hepatocellular carcinoma7 and impede T cell-dependent chemotherapy of castration-resistant prostate cancer4. This evidence concerns the gene CD4 and colorectal cancer.