Analysis for CRCs51 identified 25 top TFs, mostly overlapping with top CRC-forming TFs in MCF10DCIS cells, but we also observed some differences including gain of ELF3, ETS2, IRF2, and loss of TP63. Analysis of interaction networks among these 25 TFs identified a well-connected network with SMAD3, MYC, and SP1 as major hubs (Supplementary Fig. 4c). Here, TP63 is linked to colorectal carcinoma.