NFE2L2 and neoplasm: Moreover, the tumor plasticity observed in KrasG12D models carrying Lkb1 loss was also retained following combined loss of Keap1. The apparent dominance of SqCC tumors in KLK mice is concordant with the observed increase in Nqo1 expression and accompanying reduction in ROS levels in SqCC tumors detected in KL mice46, suggesting that augmentation of KEAP1-NRF2 pathway modulates tumor cell plasticity.