In line with mouse cell line and spontaneous tumor studies, KEAP1-mutant cell lines displayed increased sensitivity to PPP inhibition (IC50 KEAP1MUT 9.9 ± 6.4 μM vs. KEAP1WT 44.5 ± 7.9 μM; Supplementary Fig. 10d). The gene discussed is KEAP1; the disease is neoplasm.