To further explore whether the phenotype of the cancer-initiating cells directly influences the immune contexture, cell-type specific Ad5-Cre viruses were used to initiate tumors in KK and KP mice specifically in AT2 (Ad5-SPC-Cre) or bronchiolar Club (Ad5-CC10-Cre) cells in the lung7,9 (Fig. 5a). The gene discussed is SCGB1A1; the disease is cancer.