Moreover, cell lines derived from KK tumors displayed a greater clearance of reactive oxygen species (Fig. 2g), further exemplifying the enhanced function of the Nrf2 pathway in tumors with loss of Keap1. Together, these data indicate that Keap1 is a potent tumor suppressor in KrasG12D-induced lung tumorigenesis. The gene discussed is NFE2L2; the disease is neoplasm.