Moreover, over-expression of human HDAC11 in MDA-MB-231 breast cancer or 293 T cell lines, resulted in significant enrichment of the promoter regions of these genes by chromatin immunoprecipitation-qPCR (ChIP-qPCR) when probing for HDAC11 (Fig. 4b, Supplementary Fig. 7a). Here, HDAC11 is linked to breast cancer.