FLT3 and chronic myelogenous leukemia, BCR-ABL1 positive: Owing to its specificity to early myeloid lineages, spi1-driven oncogene expression was used in several additional myeloid malignancy models, e.g. involving the oncogenic fusion proteins FLT3-ITD [internal tandem duplication (ITD) of FLT3; He et al., 2014; Lu et al., 2016), tel-jak2a (CML) (Onnebo et al., 2005, 2012) and NUP98-HOXA9 (see poster: Myeloid neoplasms) (Deveau et al., 2015; Forrester et al., 2011).