AK2 and reticular dysgenesis: Morpholino knockdown was performed to mimic RD in zebrafish (Pannicke et al., 2009) and data from this study were recently confirmed by Rissone and colleagues, who aimed to generate a variety of different ak2 mutations, as seen in humans, and thus analyzed a loss-of-function ak2 mutant from a DNA library of N-ethyl-N-nitrosourea (ENU)-induced mutations (Sood et al., 2006) and furthermore generated a knockout (KO) model for ak2 by using ZFNs to introduce targeted frameshift mutations in the first exon (Rissone et al., 2015).