Although PD-L1 expression in tumors and tumor mutation burden are widely accepted as biomarkers for PD-1/PD-L1 inhibitor treatment across many cancer types, more detailed and direct immunologic analyses of TILs including irGEP have been proposed to provide additional biomarkers [6, 9, 10, 14, 24, 30, 31]. The gene discussed is CD274; the disease is neoplasm.