CXCR2 and neoplasm: Although we found a robust positive correlation between the transcript levels of SPINT1 and CXCR2, which encodes a major IL-8 receptor involved in SKCM neutrophil infiltration [36], CXCR2 has also been shown to promote tumor-induced angiogenesis and increased proliferation [37–39] and, therefore, the SPINT1/CXCR2 axis may regulate SKCM aggressiveness by neutrophil-independent pathways.