When we examined the association between B cell subsets and disease severity, the percentages of memory B cells and class-switched memory B cells were positively associated with EDSS scores only in the EDA group of IFN-β-treated MS patients (r = 0.722, p = 0.005; r = 0.719, p = 0.006, respectively), but not in the NEDA group (p = 0.601 and 0.518, respectively) (Fig. 4). The gene discussed is IFNB1; the disease is myeloid sarcoma.