AKT1 and renal cell carcinoma: The MET tyrosine kinase, an upstream activator of Akt, has been proposed to mediate TfRCC carcinogenesis [52], however the putative MET inhibitor, Tivantinib, had no objective responses and poor progression free survival (median 1.9 months) in a small number of RCC patients with a MiT family gene fusion [53].