As immunization with Ad.NY-BR-1 induced NY-BR-1-specific CD4+ T cells in EONY#17 tumor- bearing mice and since tumor antigen-specific CD4+ T cells have been reported to stimulate upregulation of MHC II expression on TAMs in the tumor microenvironment [41, 42], this might explain why the TAMs in the EONY tumors of immunized mice showed preferential expression of M1-associated markers as compared to TAMs from parental tumors. The gene discussed is CD4; the disease is neoplasm.