In another physiological context, vWF plays a role in cancer metastasis40, 41, 42 in which increased levels of vWF are associated with poor prognoses in acute myeloid leukaemia and distant metastases in lung cancer patients.43, 44 Altogether, maximum flexibility in regulating vWF release could prove therapeutically beneficial in numerous conditions. This evidence concerns the gene VWF and acute myeloid leukemia.