The implications of an augmented T-cell infiltrate during UVR-induced inflammation in EPA- and DHA-supplemented skin are uncertain: CD4+ T cells can support the development of CD8+ T cells, typically regarded as cytotoxic; so, the EPA-induced promotion of an earlier CD8+ T-cell infiltrate may condition human skin to become more resistant to inflammation and infections (58, 59). Here, CD4 is linked to infection.