There were some outcomes that had been shown to be associated with vitamin D in previous MR studies, including total adiponectin,30 multiple sclerosis,31 Alzheimer’s disease,32 cancer mortality,26 mortality excluding cancer and cardiovascular events,26 ovarian cancer,33 HDL-cholesterol,16 triglycerides16 and cognitive functions,34 but, due to limited statistical power or data availability, we did not include them in our final MR analysis. This evidence concerns the gene ADIPOQ and ovarian cancer.