Disease outcomes that were ever reported to be causally associated with vitamin D levels include type 2 diabetes (T2D), total adiponectin, diastolic blood pressure (DBP), risk of hypertension, multiple sclerosis, Alzheimer’s disease, all-cause mortality, cancer mortality, mortality excluding cancer and cardiovascular events, ovarian cancer, HDL-cholesterol, triglycerides, high-density lipoprotein, delirium and cognitive functions. This evidence concerns the gene ADIPOQ and Alzheimer disease.