There were some outcomes that had been shown to be associated with vitamin D in previous MR studies, including total adiponectin,30 multiple sclerosis,31 Alzheimer’s disease,32 cancer mortality,26 mortality excluding cancer and cardiovascular events,26 ovarian cancer,33 HDL-cholesterol,16 triglycerides16 and cognitive functions,34 but, due to limited statistical power or data availability, we did not include them in our final MR analysis. The gene discussed is ADIPOQ; the disease is multiple sclerosis.