The crucial EBNA3C role in support of LCL Rab13 expression raises the interesting question of how LMP1 and LMP2A traffic and signal in cells with latency II expression where EBNA3C is not expressed, such as in germinal center B-cells, Hodgkin Reed Sternberg (RS) or nasopharyngeal carcinoma tumor cells [12, 31, 32, 77, 120]. This evidence concerns the gene RAB13 and nasopharyngeal carcinoma.