INS and diabetes mellitus: Among n-6 PUFAs, Forouhi and colleagues reported a strong inverse association of T2DM with the most abundant plasma phospholipid LA [34] and a meta-analysis reported reduction in fasting insulin and HOMA-IR by plant-derived PUFAs (primarily LA) among people without diabetes [18], in contrast to a positive association of dietary LA with T2DM risk [47] and to our findings of null associations of LA in early to midpregnancy with GDM risk.