Many studies demonstrated that the expression of IL-1β, TNF-α, NF-κB and the number of apoptotic cells in degenerated intervertebral disc tissues were significantly higher than those in normal intervertebral disc tissues; in addition, their expression levels were positively correlated with the degree of intervertebral disc degeneration [9–10]. The gene discussed is NFKB1; the disease is Intervertebral disk degeneration.