With respect to metastasis prostate SCC, chemotherapy is regarded as the backbone; with other treatments such as androgen deprivation treatment (ADT), radiation, and AURKA inhibitors being debated.1, 21 For example, radiation is usually combined with chemotherapy, or serve as local palliative care for patients with severe obstructive symptoms or when there are no other treatment options available in the advanced stage.22 While hormone deprivation therapy is regarded as a treatment for prostate SCC mixed with adenocarcinoma.21 Here, AURKA is linked to adenocarcinoma.