CRP and Anxiety: In 2, double-blind, placebo-controlled studies, ashwagandha was associated with greater reductions in anxiety in adults presenting with predominately generalized anxiety disorder.[18,19] In an 8-week, randomized, double-blind, placebo-controlled study ashwagandha was associated with greater reductions in anxiety, morning cortisol, c-reactive protein, pulse rate, and blood pressure in chronically stressed adults.[20] Greater increases in serum dehydroepiandrosterone sulfate (DHEA-S) and hemoglobin were also noted.