At present, a large number of literatures have confirmed that F-box family protein is closely related to the occurrence and development of tumors.[20,21] F-box protein has been studied in tumor-related fields, such as FBXW7 and FBXL1, which are considered to be star molecules in the process of tumorigenesis and development.[22,23] FBXL5 can be abnormally expressed in a variety of cancer cell lines, but also can degrade and identify a variety of cancer proteins, such as p150Glued and HSSB1. Here, SKP2 is linked to cancer.